Dampak Positif Fitokimia Pycnogenol Terhadap Penyakit Kardiovaskular : Literature Review

Authors

  • Dayyan Fathiyyah Universitas Airlangga
  • Dominikus Raditya Atmaka Universitas Airlangga

DOI:

https://doi.org/10.62383/vimed.v2i3.1829

Keywords:

Cardiovascular disease, Phytochemical, Pycnogenol

Abstract

The prevalence of cardiovascular disease has continued to increase over the years, leading the World Health Organization (WHO) to designate it as a global health threat. Pycnogenol, a proprietary name for proanthocyanidins—a specific class of bioflavonoids—is known for its potent antioxidant properties. It neutralizes unstable oxygen molecules, or free radicals, that damage body cells. One of the notable benefits of Pycnogenol is its positive effect on cardiovascular health. This study aims to evaluate the effects and potential benefits of Pycnogenol consumption in relation to cardiovascular disease. This article uses a literature review method by collecting scientific articles published within the last ten years (2014–2024) from reputable online sources such as PubMed, ScienceDirect, and SpringerLink. The results of the study show that Pycnogenol, as a phytochemical compound, plays a beneficial role in maintaining cardiovascular function and preventing heart disease, atherosclerosis, and other cardiovascular conditions. All reviewed articles consistently describe the connection between Pycnogenol intake and the prevention of cardiovascular diseases. In conclusion, Pycnogenol demonstrates strong antioxidant activity that may contribute significantly to the prevention and management of cardiovascular diseases.

 

References

Ariastuti, N. L. P., Candra, G. N. H., & Swastini, D. A. (2024). Profil faktor risiko penyakit jantung koroner pada kelompok dewasa muda. Journal of Language and Health, 5(2), 787–794. https://doi.org/10.37287/jlh.v5i1.4046

Belcaro, G., Cornelli, U., Cesarone, M. R., Scipione, C., Scipione, V., Hu, S., ... & Burki, C. (2022). Preventive effects of Pycnogenol® on cardiovascular risk factors (including endothelial function) and microcirculation in subjects recovering from coronavirus disease 2019 (COVID-19). Minerva Medica, 113(3), 300–308.

Blazso, G., Gaspar, R., Gabor, M., Ruve, H. J., & Rohdewald, P. (1996). ACE inhibition and hypotensive effect of a procyanidis containing extract from the bark of Pinus pinaster Sol. Pharmaceutical and Pharmacological Letters, 6(1), 8–11.

Cahyaningrat, D., & Lukmanulhakim, L. (2020). The effect of self-management education on quality of life of clients with coronary heart disease. Jurnal Aisyah: Jurnal Ilmu Kesehatan, 5(1), 9–14.

Chen, P., Song, F., & Lin, L. Z. (2009). Chromatographic fingerprint analysis of Pycnogenol® dietary supplements. Journal of AOAC International, 92(2), 624–632.

Farahdika, A., & Azam, M. (2015). Faktor risiko yang berhubungan dengan penyakit jantung koroner pada usia dewasa madya (41–60 tahun) (studi kasus di RS Umum Daerah Kota Semarang). Unnes Journal of Public Health, 4(2).

Hu, S., Belcaro, G., Cesarone, M. R., Feragalli, B., Cotellese, R., Dugall, M., ... & Maione, C. (2019). Central cardiovascular calcifications: Supplementation with Pycnogenol® and Centellicum®: Variations over 12 months. Minerva Cardioangiologica, 68(1), 22–26.

Klimas, J., Kmecova, J., Jankyova, S., Yaghi, D., Priesolova, E., Kyselova, Z., Musil, P., Ochodnicky, P., Krenek, P., Kyselovic, J., & Matyas, S. (2010). Pycnogenol improves left ventricular function in streptozotocin-induced diabetic cardiomyopathy in rats. Phytotherapy Research, 24, 969–974.

Kralova, E., Jankyova, S., Mucaji, P., Gresakova, E., & Stankovicova, T. (2015). Pycnogenol® and its fractions influence the function of isolated heart in rats with experimental diabetes mellitus. Pathology - Research and Practice, 211(2), 156–161.

Luo, H., Wang, J., Qiao, C., Ma, N., Liu, D., & Zhang, W. (2015). Pycnogenol attenuates atherosclerosis by regulating lipid metabolism through the TLR4–NF-κB pathway. Experimental & Molecular Medicine, 47(10), e191.

Luzzi, R., Belcaro, G., Hosoi, M., Feragalli, B., Cornelli, U., Dugall, M., & Ledda, A. (2017). Normalization of cardiovascular risk factors in peri-menopausal women with Pycnogenol®. Minerva Ginecologica, 69(1), 29–34.

Martiningsih, & Haris, A. (2019). Risiko penyakit kardiovaskuler pada peserta program pengelolaan penyakit kronis (Prolanis) di Puskesmas Kota Bima: Korelasinya dengan ankle brachial index dan obesitas. Jurnal Keperawatan Indonesia, 22(3), 200–208.

Mendoza, N., & Silva, E. M. E. (2018). Introduction to phytochemicals: Secondary metabolites from plants with active principles for pharmacological. In Phytochemicals: Source of antioxidants and role in disease prevention (pp. 25). Bentham Science Publishers.

Ningsih, D. P. C., & Santika, I. W. M. (2023, November). Potensi tanaman pinus dan ekstraknya sebagai penanganan terapi pada penyakit diabetes dan kardiovaskular. In Prosiding Workshop dan Seminar Nasional Farmasi (Vol. 2, pp. 310–334).

Nurwidyaningtyas, W., Kholifah, S., & Rahma, A. (2014). Kajian kelompok risiko tinggi: Studi pendahuluan pengembangan model pengendali prevalensi penyakit kardiovaskular. Jurnal Keperawatan Indonesia, 17(1), 18–24.

Tiwari, B. K., Brunton, N., & Brennan, C. S. (2015). Handbook of plant food phytochemicals. Wiley-Blackwell.

Vasan, S., Foiles, P., & Founds, H. (2003). Therapeutic potential of breakers of advanced glycation end product–protein crosslinks. Archives of Biochemistry and Biophysics, 419(1), 89–96.

World Health Organization. (2007). Prevention of cardiovascular disease: Guidelines for assessment and management of total cardiovascular risk. World Health Organization Press. http://ish-world.com

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Published

2025-06-05

How to Cite

Dayyan Fathiyyah, & Dominikus Raditya Atmaka. (2025). Dampak Positif Fitokimia Pycnogenol Terhadap Penyakit Kardiovaskular : Literature Review . Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran, 2(3), 93–107. https://doi.org/10.62383/vimed.v2i3.1829

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