Hubungan antara Konsumsi Makanan Ultra-Processed Food (UPF) dengan Asupan Zat Besi dan Risiko Anemia: Tinjauan Naratif

Authors

  • Nabila Nuraisyah Rizkianti Universitas Airlangga
  • Trias Mahmudiono Universitas Airlangga

DOI:

https://doi.org/10.62383/ikg.v3i1.2855

Keywords:

Anemia, Micronutrients, Nutritional Status, Iron, Ultra-Processed Foods

Abstract

The consumption of ultra-processed foods (UPF) has been increasing among various age groups, including children and adults. UPF is generally low in iron content and can interfere with iron bioavailability, thereby increasing the risk of anemia. Additionally, the high calorie content of UPF contributes to the development of degenerative diseases. This study aims to analyze the relationship between UPF consumption, iron intake, and the risk of anemia. The study employs a narrative review method. Literature search was conducted using PubMed, Google Scholar, and Scopus databases, using controlled terms. The results showed that high UPF consumption had a negative impact on iron intake and increased the risk of anemia. Similar effects were found in high fat and sodium consumption. Some studies showed varying results regarding protein intake, fiber, and micronutrients such as sodium and calcium. In general, it can be concluded that excessive UPF consumption negatively impacts the quality of nutrient intake, both macro and micro, and contributes to the occurrence of anemia. These findings highlight the need for public health strategies to limit UPF consumption, particularly among vulnerable populations, as a preventive effort against anemia.

References

Achebe, M. M., & Gafter-Gvili, A. (2016). How I treat anemia in pregnancy: Iron, cobalamin, and folate. Blood, 129(8), 940–949. https://doi.org/10.1182/blood-2016-08-672246

Aguree, S., Owora, A., Hawkins, M., & Reddy, M. B. (2023). Iron deficiency and iron deficiency anemia in women with and without obesity: NHANES 2001–2006. Nutrients, 15(10), 2272. https://doi.org/10.3390/nu15102272

Allali, S., Brousse, V., Sacri, A., Chalumeau, M., & De Montalembert, M. (2017). Anemia in children: Prevalence, causes, diagnostic work-up, and long-term consequences. Expert Review of Hematology, 10(11), 1023–1028. https://doi.org/10.1080/17474086.2017.1354696

Antoniazzi, L., De Miranda, R. C., Rauber, F., De Moraes, M. M., Afonso, C., Santos, C., Lopes, C., Rodrigues, S., & Levy, R. B. (2022). Ultra-processed food consumption deteriorates the profile of micronutrients consumed by Portuguese adults and elderly: The UPPER project. European Journal of Nutrition, 62(3), 1131–1141. https://doi.org/10.1007/s00394-022-03057-w

Bhowmik, B., Moreira, N. C. D. V., Basit, A., & Hussain, A. (2018). Maternal nutrition during early pregnancy and cardiometabolic status of neonates at birth. Journal of Diabetes Research, 2018, 1–8. https://doi.org/10.1155/2018/7382946

Bielemann, R. M., Motta, J. V. S., Minten, G. C., Horta, B. L., & Gigante, D. P. (2015). Consumption of ultra-processed foods and their impact on the diet of young adults. Revista De Saúde Pública, 49(0), 28. https://doi.org/10.1590/s0034-8910.2015049005572

Biete, A., Gonçalves, V., Crispim, S., Franceschini, S., Carmo, A., & Pizato, N. (2023). Ultra-processed foods and schooling are independently associated with lower iron and folate consumption by pregnant women followed in primary health care. International Journal of Environmental Research and Public Health, 20(12), 6063. https://doi.org/10.3390/ijerph20126063

Camaschella, C., Pagani, A., Silvestri, L., & Nai, A. (2022). The mutual crosstalk between iron and erythropoiesis. International Journal of Hematology, 116(2), 182–191. https://doi.org/10.1007/s12185-022-03384-y

Chen, X., Zhang, Z., Yang, H., Qiu, P., Wang, H., Wang, F., Zhao, Q., Fang, J., & Nie, J. (2020). Consumption of ultra-processed foods and health outcomes: A systematic review of epidemiological studies. Nutrition Journal, 19(1). https://doi.org/10.1186/s12937-020-00604-1

Colozza, D. (2022). A qualitative exploration of ultra-processed foods consumption and eating out behaviours in an Indonesian urban food environment. Nutrition and Health, 30(3), 613–623. https://doi.org/10.1177/02601060221133897

Dallazen, C., Da Silva, S. A., Gonçalves, V. S. S., Nilson, E. A. F., Crispim, S. P., Lang, R. M. F., Moreira, J. D., Tietzmann, D. C., & Vítolo, M. R. (2018). Introdução de alimentos não recomendados no primeiro ano de vida e fatores associados em crianças de baixo nível socioeconômico. Cadernos De Saúde Pública, 34(2). https://doi.org/10.1590/0102-311x00202816

Dongiovanni, P., Lanti, C., Gatti, S., Rametta, R., Recalcati, S., Maggioni, M., Fracanzani, A. L., Riso, P., Cairo, G., Fargion, S., & Valenti, L. (2015). High fat diet subverts hepatocellular iron uptake determining dysmetabolic iron overload. PLoS ONE, 10(2), e0116855. https://doi.org/10.1371/journal.pone.0116855

Figueiredo, A., Gomes-Filho, I., Silva, R., Pereira, P., Mata, F., Lyrio, A., Souza, E., Cruz, S., & Pereira, M. (2018). Maternal anemia and low birth weight: A systematic review and meta-analysis. Nutrients, 10(5), 601. https://doi.org/10.3390/nu10050601

Fu, J., Zeng, C., Huang, J., Guo, J., Su, Z., Luo, S., Zhang, W., Zhang, Z., Zhu, H., & Li, Y. (2024). Dietary patterns and association with iron deficiency among children and adolescents aged 9–17 years in rural Guangzhou, China: A cross-sectional study. Frontiers in Nutrition, 11, 1443849. https://doi.org/10.3389/fnut.2024.1443849

Graciliano, N. G., Da Silveira, J. A. C., & De Oliveira, A. C. M. (2021). Consumo de alimentos ultraprocessados reduz a qualidade global da dieta de gestantes. Cadernos De Saúde Pública, 37(2). https://doi.org/10.1590/0102-311x00030120

Granich-Armenta, A., Contreras-Manzano, A., Cantoral, A., Christensen, D. L., Marrón-Ponce, J. A., Ávila-Jímenez, L., Ramírez-Silva, I., Dommarco, J. A. R., Grunnet, L. G., Bygbjerg, I. C., & Lamadrid-Figueroa, H. (2024). Differential dietary intake and contribution of ultra-processed foods during pregnancy according to nutritional status. Frontiers in Nutrition, 11, 1400513. https://doi.org/10.3389/fnut.2024.1400513

Haghighatdoost, F., Hajihashemi, P., Mohammadifard, N., Najafi, F., Farshidi, H., Lotfizadeh, M., Kazemi, T., Karimi, S., Shirani, S., Solati, K., & Sarrafzadegan, N. (2022). Association between ultra-processed foods consumption and micronutrient intake and diet quality in Iranian adults: A multicentric study. Public Health Nutrition, 26(2), 467–475. https://doi.org/10.1017/s1368980022002038

Harder, N. H. O., Hieronimus, B., Stanhope, K. L., Shibata, N. M., Lee, V., Nunez, M. V., Keim, N. L., Bremer, A., Havel, P. J., Heffern, M. C., & Medici, V. (2020). Effects of dietary glucose and fructose on copper, iron, and zinc metabolism parameters in humans. Nutrients, 12(9), 2581. https://doi.org/10.3390/nu12092581

He, W., Li, X., Ding, K., Li, Y., & Li, W. (2018). Ascorbic acid can reverse the inhibition of phytic acid, sodium oxalate, and sodium silicate on iron absorption in Caco-2 cells. International Journal for Vitamin and Nutrition Research, 88(1–2), 65–72. https://doi.org/10.1024/0300-9831/a000503

Heerman, W. J., Sneed, N. M., Sommer, E. C., Truesdale, K. P., Matheson, D., Noerper, T. E., Samuels, L. R., & Barkin, S. L. (2023). Ultra‐processed food consumption and BMI‐Z among children at risk for obesity from low‐income households. Pediatric Obesity, 18(8). https://doi.org/10.1111/ijpo.13037

Houshialsadat, Z., Cediel, G., Sattamini, I., Scrinis, G., & Machado, P. (2023). Ultra-processed foods, dietary diversity and micronutrient intakes in the Australian population. European Journal of Nutrition, 63(1), 135–144. https://doi.org/10.1007/s00394-023-03245-2

Janbek, J., Sarki, M., Specht, I. O., & Heitmann, B. L. (2019). A systematic literature review of the relation between iron status/anemia in pregnancy and offspring neurodevelopment. European Journal of Clinical Nutrition, 73(12), 1561–1578. https://doi.org/10.1038/s41430-019-0400-6

Jayasinghe, C., Polson, R., Van Woerden, H. C., & Wilson, P. (2018). The effect of universal maternal antenatal iron supplementation on neurodevelopment in offspring: A systematic review and meta-analysis. BMC Pediatrics, 18(1). https://doi.org/10.1186/s12887-018-1118-7

Juul, F., Parekh, N., Martinez-Steele, E., Monteiro, C. A., & Chang, V. W. (2021). Ultra-processed food consumption among US adults from 2001 to 2018. American Journal of Clinical Nutrition, 115(1), 211–221. https://doi.org/10.1093/ajcn/nqab305

Kehoe, L., Buffini, M., McNulty, B. A., Kearney, J. M., Flynn, A., & Walton, J. (2022). Food and nutrient intakes and compliance with recommendations in school-aged children in Ireland: Findings from the National Children’s Food Survey II (2017–2018) and changes since 2003–2004. British Journal of Nutrition, 129(11), 2011–2024. https://doi.org/10.1017/s0007114522002781

Khandpur, N., Cediel, G., Obando, D. A., Jaime, P. C., & Parra, D. C. (2020). Sociodemographic factors associated with the consumption of ultra-processed foods in Colombia. Revista De Saúde Pública, 54, 19. https://doi.org/10.11606/s1518-8787.2020054001176

Kroker-Lobos, M. F., Mazariegos, M., Guamuch, M., & Ramirez-Zea, M. (2022). Ultraprocessed products as food fortification alternatives: A critical appraisal from Latin America. Nutrients, 14(7), 1413. https://doi.org/10.3390/nu14071413

Kusmiati, E., Sugandi, E. S., Lubis, S., Hayati, I. M., & Nasrullah, M. H. (2025). The influence of ultra-processed food on childhood obesity: A systematic review. Journal Educational of Nursing (JEN), 8(1), 12–24. https://doi.org/10.37430/jen.v8i1.243

Latunde-Dada, G. O. (2024). Iron intake and human health. Nutrients, 16(2), 206. https://doi.org/10.3390/nu16020206

Marrone, G., Guerriero, C., Palazzetti, D., Lido, P., Marolla, A., Di Daniele, F., & Noce, A. (2021). Vegan diet health benefits in metabolic syndrome. Nutrients, 13(3), 817. https://doi.org/10.3390/nu13030817

Means, R. T. (2020). Iron deficiency and iron deficiency anemia: Implications and impact in pregnancy, fetal development, and early childhood parameters. Nutrients, 12(2), 447. https://doi.org/10.3390/nu12020447

Monteiro, C. A., Cannon, G., Levy, R. B., Moubarac, J., Louzada, M. L., Rauber, F., Khandpur, N., Cediel, G., Neri, D., Martinez-Steele, E., Baraldi, L. G., & Jaime, P. C. (2019). Ultra-processed foods: What they are and how to identify them. Public Health Nutrition, 22(5), 936–941. https://doi.org/10.1017/s1368980018003762

Morales-Suarez-Varela, M., & Rocha-Velasco, O. A. (2024). Impact of ultra-processed food consumption during pregnancy on maternal and child health outcomes: A comprehensive narrative review of the past five years. Clinical Nutrition ESPEN, 65, 288–304. https://doi.org/10.1016/j.clnesp.2024.12.006

O’Keefe, J. H., O’Keefe, E. L., Lavie, C. J., & Cordain, L. (2022). Debunking the vegan myth: The case for a plant-forward omnivorous whole-foods diet. Progress in Cardiovascular Diseases, 74, 2–8. https://doi.org/10.1016/j.pcad.2022.08.001

Oviedo-Solís, C., Monterrubio-Flores, E., Cediel, G., Denova-Gutiérrez, E., & Barquera, S. (2022). Trend of ultraprocessed product intake is associated with the double burden of malnutrition in Mexican children and adolescents. Nutrients, 14(20), 4347. https://doi.org/10.3390/nu14204347

Pagliai, G., Dinu, M., Madarena, M. P., Bonaccio, M., Iacoviello, L., & Sofi, F. (2020). Consumption of ultra-processed foods and health status: A systematic review and meta-analysis. British Journal of Nutrition, 125(3), 308–318. https://doi.org/10.1017/s0007114520002688

Paula, W. O., Gonçalves, V. S. S., Patriota, E. S. O., Franceschini, S. C. C., & Pizato, N. (2023). Impact of ultra-processed food consumption on quality of diet among Brazilian pregnant women assisted in primary health care. International Journal of Environmental Research and Public Health, 20(2), 1015. https://doi.org/10.3390/ijerph20021015

Percy, L., Mansour, D., & Fraser, I. (2016). Iron deficiency and iron deficiency anaemia in women. Best Practice & Research Clinical Obstetrics & Gynaecology, 40, 55–67. https://doi.org/10.1016/j.bpobgyn.2016.09.007

Pries, A. M., Filteau, S., & Ferguson, E. L. (2019). Snack food and beverage consumption and young child nutrition in low- and middle-income countries: A systematic review. Maternal and Child Nutrition, 15(S4), e12729. https://doi.org/10.1111/mcn.12729

Queiroz, J. C. D. L. S., Rey, L. C., Da Rocha Ataide, T., De Menezes Toledo Florêncio, T. M., & Silva-Neto, L. G. R. (2024). Consumption of ultra-processed foods is associated with dietary iron availability, anemia, and excess weight in socially vulnerable children. Clinical Nutrition ESPEN, 65, 461–468. https://doi.org/10.1016/j.clnesp.2024.12.023

Riaz, M., Shaikh, F., Fawwad, A., Hakeem, R., Shera, A. S., Hitman, G. A., & Safety, N. A. F. (2014, December 30). Global nutrition targets 2025: Anaemia policy brief. World Health Organization. https://www.who.int/publications/i/item/WHO-NMH-NHD-14.4

Sartorelli, D. S., Crivellenti, L. C., Zuccolotto, D. C. C., & Franco, L. J. (2019). Relationship between minimally and ultra-processed food intake during pregnancy with obesity and gestational diabetes mellitus. Cadernos De Saúde Pública, 35(4). https://doi.org/10.1590/0102-311x00049318

Semla, M., Goc, Z., Martiniaková, M., Omelka, R., & Formicki, G. (2017). Acrylamide: A common food toxin related to physiological functions and health. Physiological Research, 205–217. https://doi.org/10.33549/physiolres.933381

Shim, J., Shim, S., Cha, H., Kim, J., & Kim, H. C. (2021). Socioeconomic characteristics and trends in the consumption of ultra-processed foods in Korea from 2010 to 2018. Nutrients, 13(4), 1120. https://doi.org/10.3390/nu13041120

Skolmowska, D., & Głąbska, D. (2019). Analysis of HEME and non-HEME iron intake and iron dietary sources in adolescent menstruating females in a national Polish sample. Nutrients, 11(5), 1049. https://doi.org/10.3390/nu11051049

Sunuwar, D. R., Singh, D. R., Chaudhary, N. K., Pradhan, P. M. S., Rai, P., & Tiwari, K. (2020). Prevalence and factors associated with anemia among women of reproductive age in seven South and Southeast Asian countries: Evidence from nationally representative surveys. PLoS ONE, 15(8), e0236449. https://doi.org/10.1371/journal.pone.0236449

Verhoef, H., Mwangi, M. N., Cerami, C., & Prentice, A. M. (2019). Antenatal iron supplementation and birth weight in conditions of high exposure to infectious diseases. BMC Medicine, 17(1). https://doi.org/10.1186/s12916-019-1375-9

Vos, T., Abajobir, A. A., Abate, K. H., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abdulkader, R. S., Abdulle, A. M., Abebo, T. A., Abera, S. F., Aboyans, V., Abu-Raddad, L. J., Ackerman, I. N., Adamu, A. A., Adetokunboh, O., Afarideh, M., Afshin, A., Agarwal, S. K., Aggarwal, R., . . . Murray, C. J. L. (2017). Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. The Lancet, 390(10100), 1211–1259. https://doi.org/10.1016/s0140-6736(17)32154-2

Wade, J., Byrne, D. J., Ballentine, C. J., & Drakesmith, H. (2021). Temporal variation of planetary iron as a driver of evolution. Proceedings of the National Academy of Sciences, 118(51). https://doi.org/10.1073/pnas.2109865118

Downloads

Published

2026-01-27

How to Cite

Nabila Nuraisyah Rizkianti, & Trias Mahmudiono. (2026). Hubungan antara Konsumsi Makanan Ultra-Processed Food (UPF) dengan Asupan Zat Besi dan Risiko Anemia: Tinjauan Naratif. Inovasi Kesehatan Global, 3(1), 242–258. https://doi.org/10.62383/ikg.v3i1.2855

Similar Articles

1 2 3 4 > >> 

You may also start an advanced similarity search for this article.