Tinjauan Sistematis Senyawa Metabolit Bioaktif Buah Pepaya (Carica papaya L.) Karakterisasi Kimia dan Aplikasinya dalam Bidang Kesehatan
DOI:
https://doi.org/10.62383/ikg.v3i1.2812Keywords:
Bioactive Metabolites, Carica Papaya L, Chemical Characterization, Health, Papaya Fruit.Abstract
Papaya fruit (Carica papaya L.) is a tropical plant widely consumed as food and known to contain various bioactive metabolites with potential health benefits. The increasing interest in natural products as functional resources highlights the importance of reviewing the chemical characterization and health applications of papaya bioactive compounds. This article aims to systematically review the types of bioactive metabolites found in papaya fruit, the chemical characterization methods applied, and their potential applications in the health sector. This review was conducted through a literature study of relevant scientific articles, focusing on metabolite identification and biological activity evaluation. The results indicate that papaya fruit contains diverse bioactive metabolites, including flavonoids, phenolic compounds, alkaloids, saponins, terpenoids, and proteolytic enzymes. These compounds are commonly characterized using chromatographic and spectroscopic techniques. Several studies have reported that papaya bioactive metabolites exhibit biological activities such as antioxidant, antimicrobial, anti-inflammatory, and antidiabetic effects. This review suggests that papaya fruit has promising potential as a functional natural resource for health and pharmaceutical applications.
References
Alves, N. F., Guimarães, A. L., da Silva, J. K., & Santos, E. L. (2017). Phenolic compounds and antioxidant activity of tropical fruits consumed in Brazil. Journal of Food Biochemistry, 41(6), e12407. https://doi.org/10.1111/jfbc.12407
Aravind, G., Bhowmik, D., Duraivel, S., & Harish, G. (2013). Traditional and medicinal uses of Carica papaya. Journal of Medicinal Plants Studies, 1(1), 7–15.
Azmir, J., Zaidul, I. S. M., Rahman, M. M., Sharif, K. M., Mohamed, A., Sahena, F., Jahurul, M. H. A., Ghafoor, K., Norulaini, N. A. N., & Omar, A. K. M. (2013). Techniques for extraction of bioactive compounds from plant materials: A review. Journal of Food Engineering, 117(4), 426–436. https://doi.org/10.1016/j.jfoodeng.2013.01.014
Baskaran, C., Ratha Bai, V., & Velu, S. (2016). Evaluation of antimicrobial activity and phytochemical analysis of Carica papaya fruit extracts. Journal of Chemical and Pharmaceutical Research, 8(2), 396–402.
Deng, G. F., Xu, X. R., Zhang, Y., Li, D., Gan, R. Y., & Li, H. B. (2015). Phenolic compounds and antioxidant activities of fruits and vegetables consumed in China. Food Chemistry, 169, 372–380. https://doi.org/10.1016/j.foodchem.2014.07.116
Juárez-Rojop, I. E., Díaz-Zagoya, J. C., Ble-Castillo, J. L., Miranda-Osorio, P. H., Castell-Rodríguez, A. E., Tovilla-Zárate, C. A., Rodríguez-Hernández, A., Aguilar-Mariscal, H., & Bermúdez-Ocaña, D. Y. (2014). Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats. BMC Complementary and Alternative Medicine, 14, Article 236. https://doi.org/10.1186/1472-6882-14-236
Krishna, K. L., Paridhavi, M., & Patel, J. A. (2008). Review on nutritional, medicinal and pharmacological properties of papaya (Carica papaya Linn.). Natural Product Radiance, 7(4), 364–373.
Liu, R. H. (2013). Health-promoting components of fruits and vegetables in the diet. Advances in Nutrition, 4(3), 384S–392S. https://doi.org/10.3945/an.112.003517
Maisarah, A. M., Asmah, R., & Fauziah, O. (2013). Antioxidant analysis of different parts of Carica papaya. International Food Research Journal, 20(3), 1043–1048.
Oloyede, O. I., Afolayan, A. J., & Ogunbodede, B. A. (2015). Antimicrobial and phytochemical evaluation of Carica papaya fruit extracts. Journal of Medicinal Plants Research, 9(9), 247–252. https://doi.org/10.5897/JMPR2014.5623
Patel, R. K., Jain, S. K., & Yadav, S. K. (2016). Papain: A plant enzyme of biological importance. International Journal of Pharmaceutical Sciences and Research, 7(5), 2041–2047. https://doi.org/10.13040/IJPSR.0975-8232.7(5).2041-47
Rivera-Pastrana, D. M., Yahia, E. M., & González-Aguilar, G. A. (2016). Phenolic and carotenoid profiles of papaya fruit (Carica papaya L.) and their contents under different ripening stages. Food Chemistry, 198, 108–117.
Rohman, A., Windarsih, A., Lukitaningsih, E., & Sudjadi. (2015). Application of FTIR spectroscopy combined with multivariate calibration for analysis of bioactive compounds in herbal products. International Journal of Food Properties, 18(7), 1–12. https://doi.org/10.1080/10942912.2013.833221
Santos, D. T., Veggi, P. C., & Meireles, M. A. A. (2016). Optimization and economic evaluation of phenolic compounds extraction from agro-industrial residues. Food and Bioproducts Processing, 100, 163–172.
Silva, F. A. M., Borges, F., & Guimarães, C. (2017). Phenolic compounds and antioxidant activity of tropical fruits. Food Chemistry, 220, 169–176.
Sulaiman, S. F., Sajak, A. A. B., Ooi, K. L., Supriatno, & Seow, E. M. (2015). Effect of solvents in extracting polyphenols and antioxidants of selected raw vegetables. Journal of Food Composition and Analysis, 44, 157–165.
Vuong, Q. V., Hirun, S., Phillips, P. A., Chuen, T. L. K., Bowyer, M. C., Goldsmith, C. D., & Scarlett, C. J. (2017). Fruit-derived phenolic compounds and their biological activities. Food Chemistry, 221, 162–170.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Inovasi Kesehatan Global
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
