Pengaruh Ekstrak Daun Jarak (Jatropha curcas) terhadap Peradangan

Authors

  • Muhammad Zahran Saputra Universitas Adiwangsa Jambi
  • Ardi Mustakim Universitas Adiwangsa Jambi

DOI:

https://doi.org/10.62383/ikg.v3i1.2828

Keywords:

Anti-Inflammatory, Herbal Medicine, Jatropha Curcas, Leaf Extract, Medicinal Plants

Abstract

Inflammation is a biological response that occurs as a defense mechanism of the body against tissue damage, infection, or exposure to harmful stimuli. Excessive or prolonged inflammation can lead to various chronic diseases and negatively affect overall health. Natural compounds derived from medicinal plants have gained attention as alternative anti-inflammatory agents due to their relatively lower side effects compared to synthetic drugs. Jatropha curcas is a plant traditionally used in herbal medicine and is known to contain various bioactive compounds. This study aims to examine the effect of Jatropha curcas leaf extract on inflammatory responses. The research method used was an experimental laboratory approach with extract preparation through maceration techniques. The anti-inflammatory effect was evaluated based on changes in inflammatory indicators observed during the treatment process. The results showed that Jatropha curcas leaf extract demonstrated potential anti-inflammatory activity, which was indicated by a reduction in inflammatory signs. The presence of secondary metabolites such as flavonoids, tannins, and saponins is suspected to contribute to this effect. These findings suggest that Jatropha curcas leaf extract has promising potential as a natural anti-inflammatory agent. Further research is recommended to explore dosage optimization and toxicity levels for safe therapeutic use.

 

References

Adeosun, T. E., Ogunwande, I. A., Avoseh, O. N., Raji, I. P., & Lawal, O. A. (2017). Composition and anti-inflammatory activity of essential oil of Jatropha curcas. Natural Product Communications, 12(3). https://doi.org/10.1177/1934578X1701200333

AG, A., OK, A., OP, B., RB, S., MO, A., IA, E., … AN, A. (2023). Phytochemical screening, in vitro antioxidant and anti-inflammatory activity of aqueous extract of Jatropha curcas. South Asian Research Journal of Natural Products, 6(3), 239–247.

Arif, M. A., Ifora, I., Srangenge, Y., & Fauziah, F. (2020). Potential anti-inflammatory effects of Jatropha curcas L.: A review. Journal of Pharmaceutical Sciences, 5, 11–16.

Baroroh, H. N., Iskandar, S., Rachmani, E. P. N., Hertiani, T., & Ikawati, Z. (2014). Jatropha curcas leaves exert anti-arthritic activity on adjuvant-induced arthritis in rats. Universa Medicina, 33(1), 3–10.

Bhale, R. A., Sanap, G., & Wagh, A. (n.d.). Jatropha curcas.

De Amorim, V. C. M., Júnior, M. S. O., da Silva, A. B., David, J. M., David, J. P. L., de Fátima Dias Costa, M., … Costa, S. L. (2020). Agathisflavone modulates astrocytic responses and increases the population of neurons in an in vitro model of traumatic brain injury. Naunyn-Schmiedeberg’s Archives of Pharmacology, 393(10), 1921–1930. https://doi.org/10.1007/s00210-020-01905-2

De Souza, A. A., Ortíz, B. L. S., Borges, S. F., Pinto, A. V. P., Ramos, R. D. S., Pena, I. C., … Tavares Carvalho, J. C. (2022). Acute toxicity and anti-inflammatory activity of Trattinnickia rhoifolia Willd (Sucuruba) using the zebrafish model. Molecules, 27(22), 7741. https://doi.org/10.3390/molecules27227741

El-Saadony, M. T., Saad, A. M., Mohammed, D. M., Korma, S. A., Alshahrani, M. Y., Ahmed, A. E., … Ibrahim, S. A. (2025). Medicinal plants: Bioactive compounds, biological activities, combating multidrug-resistant microorganisms, and human health benefits—A comprehensive review. Frontiers in Immunology, 16, 1491777. https://doi.org/10.3389/fimmu.2025.1491777

Ferreira-Rodrigues, S. C., Rodrigues, C. M., Dos Santos, M. G., Gautuz, J. A. A., Silva, M. G., Cogo, J. C., … Oshima-Franco, Y. (2016). Anti-inflammatory and antibothropic properties of Jatropha elliptica, a plant from Brazilian cerrado biome. Advanced Pharmaceutical Bulletin, 6(4), 573–580. https://doi.org/10.15171/apb.2016.071

Jiménez-Nevárez, Y. B., Angulo-Escalante, M. A., Montes-Avila, J., Guerrero-Alonso, A., Christen, J. G., Hurtado-Díaz, I., … Alvarez, L. (2023). Phytochemical characterization and in vitro anti-inflammatory evaluation in RAW 264.7 cells of Jatropha cordata bark extracts. Plants, 12(3), 560. https://doi.org/10.3390/plants12030560

Mujumdar, A. M., & Misar, A. V. (2004). Anti-inflammatory activity of Jatropha curcas roots in mice and rats. Journal of Ethnopharmacology, 90(1), 11–15. https://doi.org/10.1016/j.jep.2003.09.019

Othman, A. R., Abdullah, N., Ahmad, S., Ismail, I. S., & Zakaria, M. P. (2015). Elucidation of in vitro anti-inflammatory bioactive compounds isolated from Jatropha curcas L. plant root. BMC Complementary and Alternative Medicine, 15, 11. https://doi.org/10.1186/s12906-015-0528-4

Ramothloa, T. P., Mkolo, N. M., Motshudi, M. C., Mphephu, M. M., Makhafola, M. A., & Naidoo, C. M. (2025). Phytochemical composition and multifunctional applications of Ricinus communis L.: Insights into therapeutic, pharmacological, and industrial potential. Molecules, 30(15), 3214. https://doi.org/10.3390/molecules30153214

Rampadarath, S., Puchooa, D., & Jeewon, R. (2016). Jatropha curcas L.: Phytochemical, antimicrobial, and larvicidal properties. Asian Pacific Journal of Tropical Biomedicine, 6(10), 858–865. https://doi.org/10.1016/j.apjtb.2016.01.019

Salim, M. N., Masyitha, D., Harris, A., Balqis, U., Iskandar, C. D., & Hambal, M. (2018). Anti-inflammatory activity of Jatropha curcas Linn. latex in cream formulation on CD68 expression in mice skin wound. Veterinary World, 11(2), 99–103. https://doi.org/10.14202/vetworld.2018.99-103

Sánchez-Ramos, M., Ruiz-Betancourt, A., Tadeo-Cuenca, S. A., Román-Guerrero, A., Columba-Palomares, M. C., Guerrero-Alonso, A., … Cruz-Sosa, F. (2025). The role of Latin American medicinal plants in wound healing. Frontiers in Chemical Engineering, 6, 1514962. https://doi.org/10.3389/fceng.2024.1514962

Srinivasan, N., Palanisamy, K., & Mulpuri, S. (2019). Jatropha: Phytochemistry, pharmacology, and toxicology. In Jatropha, challenges for a new energy crop (Vol. 3, pp. 415–435). Springer. https://doi.org/10.1007/978-981-13-3104-6_20

Tripathi, Y., Sharma, A., Gangwar, M., Shukla, R., & Pandey, N. (2016). Antimicrobial and anti-inflammatory activity of press cake of Jatropha curcas. Applied Microbiology: Open Access, 2, 1000116. https://doi.org/10.4172/2471-9315.1000116

Widarti, L., Suprianto, S., & Maimuna, S. (2023). Utilization of Jatropha curcas L. leaf extract gel for improving temperature, infarct volume, TNF-α, and IL-1β in post-ischemic brain mice. Tropical Journal of Natural Product Research, 7(12). https://doi.org/10.26538/tjnpr/v7i12.40

Yadav, P., Bharti, N., Kansotiya, A. K., Kumari, S., Yadav, R. K., & Mali, P. C. (2023). Potential antifertility and antimicrobial activities of plants used in traditional medicines: A review. Journal of Pharmacognosy and Phytochemistry, 12(2), 190–198. https://doi.org/10.22271/phyto.2023.v12.i2c.14650

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Published

2026-01-23

How to Cite

Muhammad Zahran Saputra, & Ardi Mustakim. (2026). Pengaruh Ekstrak Daun Jarak (Jatropha curcas) terhadap Peradangan. Inovasi Kesehatan Global, 3(1), 195–205. https://doi.org/10.62383/ikg.v3i1.2828

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