Literature Review: Pengaruh Sorgum Manis sebagai Immunomodulator

Authors

  • Ghina Rania Rizmananda Universitas Airlangga

DOI:

https://doi.org/10.62383/quwell.v2i2.2049

Keywords:

Sorghum bicolor, Immune, Inflammation

Abstract

Sweet Sorghum )Sorghum Bicolor) is a group of cereals that have health benefits for the body. There are antioxidant and anti-inflammatory contents in sweet gandrung which are believed to provide immune effects. The study aims to determine the relationship between giving sweet gandrung and the antioxidant and anti-inflammatory activities of sorghum as an immunomodulator through existing clinical and experimental trials. Meta-analysis was conducted by collecting, collecting and analyzing data through 4 relevant journals. Studies were selected based on inclusion and exclusion criteria. The results of the meta-analysis showed that there was a significant difference in giving a sweet gandrung diet with antioxidant activity, decreased lymphocytes (p <0.05) in inflammation. There was a significant effect of giving a dose of sweet gandrung in the form of extract or Jobelyn in reducing lymphocyte levels and showing antioxidant and anti-inflammatory activity that acts as a protector against tissue damage

References

Adebesin, A., Omogbiya, A. I., Oluwole, O. G., Okubena, O., Asomadu, R. O., Afolabi, M. O. S., Makanjuola, S. B. L., Ajonuma, L. C., Dosunmu, A. O., Otitoloju, O., & Umukoro, S. (2024). An evidence-based systematic review of pleiotropic potential health benefits of Sorghum bicolor supplement: A polyphenol-rich derivative of the leaf sheaths of sorghum plant. Journal of Natural Remedies, 24(4), 683–702. https://doi.org/10.18311/jnr/2024/33171

Ayuba, G. I., Jensen, G. S., Benson, K. F., Okubena, A. M., & Okubena, O. (2014). Clinical efficacy of a West African Sorghum bicolor-based traditional herbal preparation Jobelyn shows increased hemoglobin and CD4+ T-lymphocyte counts in HIV-positive patients. Journal of Alternative and Complementary Medicine, 20(1), 53–56. https://doi.org/10.1089/acm.2013.0125

Benson, K. F., Beaman, J. L., Ou, B., Okubena, A., Okubena, O., & Jensen, G. S. (2013). West African Sorghum bicolor leaf sheaths have anti-inflammatory and immune-modulating properties in vitro. Journal of Medicinal Food, 16(3), 230–238. https://doi.org/10.1089/jmf.2012.0214

Chowdhury, M. A., Hossain, N., Kashem, M. A., Shahid, M. A., & Alam, A. (2020). Immune response in COVID-19: A review. Journal of Infection and Public Health, 13(11), 1619–1629. https://doi.org/10.1016/j.jiph.2020.07.001

Fadlilah, A., & Lestari, E. D. (2023). Peran antioksidan dalam imunitas tubuh: Tinjauan literatur. Jurnal Farmaka, 21(1), 45–53.

Ilyas, M. Y., Diantini, A., Ghozali, M., Sahidin, I., & Fristiohady, A. (2022). Immunomodulatory potency Etlingera rubroloba A.D. Poulsen fruit ethanol extract against macrophage phagocytic activity and CD4 levels in Wistar male rats. Research Journal of Pharmacy and Technology, 15(9), 4067–4072.

Khalid, W., Ali, A., Arshad, M. S., Afzal, F., Akram, R., Siddeeg, A., Kousar, S., Rahim, M. A., Aziz, A., Maqbool, Z., & Saeed, A. (2022). Nutrients and bioactive compounds of Sorghum bicolor L. used to prepare functional foods: A review on the efficacy against different chronic disorders. International Journal of Food Properties, 25(1), 1045–1062. https://doi.org/10.1080/10942912.2022.2071293

Liu, Z., Huang, X., Chen, Y., Xue, J., Xie, Q., Zhong, H., & Luo, Y. (2025). Dietary sweet sorghum (Sorghum bicolor (L.) Moench) inclusion in geese: Impacts on growth performance, blood biochemistry, and intestinal health. Journal of Animal Nutrition, Advance online publication, 1–14.

Mallu, M. R., Ronda, S. R., Kamma, S., Golamari, S. R., & Vemula, S. (2018). Hematological and immunomodulatory evaluation of methanolic extract of Sorghum bicolor leaves. International Journal of Green Pharmacy, 12(1), S173–S176.

Puluhulawa, L. E., & Paneo, M. A. (2024). Peningkatan pemahaman masyarakat mengenai penyakit akibat infeksi di Puskesmas Kota Timur Gorontalo. Jurnal Pengabdian Masyarakat Farmasi: Pharmacare Society, 3(1), 1–6. https://doi.org/10.37905/phar.soc.v3i1.24944

Punia, H., Tokas, J., Malik, A., Satpal, & Sangwan, S. (2021). Characterization of phenolic compounds and antioxidant activity in sorghum [Sorghum bicolor (L.) Moench] grains. Cereal Research Communications, 49(3), 343–353. https://doi.org/10.1007/s42976-020-00118-w

Vidisha, U. (2020). A review on immunomodulators. Journal of Pharmacognosy and Phytochemistry, 9(1), 1289–1292.

Wang, R., Lan, C., Benlagha, K., Camara, N. O. S., Miller, H., Kubo, M., Heegaard, S., Lee, P., Yang, L., Forsman, H., Li, X., Zhai, Z., & Liu, C. (2024). The interaction of innate immune and adaptive immune system. MedComm, 5(10), e714. https://doi.org/10.1002/mco2.714

Wasityastuti, W., Dhamarjati, A., & Siswanto. (2020). Imunosenesens dan kerentanan populasi usia lanjut terhadap Coronavirus Disease 2019 (Covid-19). Respirologi Indonesia, 40(3), 182–191.

Xu, J., Wang, W., & Zhao, Y. (2021). Phenolic compounds in whole grain sorghum and their health benefits. Foods, 10(8). https://doi.org/10.3390/foods10081921

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Published

2025-06-25

How to Cite

Ghina Rania Rizmananda. (2025). Literature Review: Pengaruh Sorgum Manis sebagai Immunomodulator. Quantum Wellness : Jurnal Ilmu Kesehatan, 2(2), 297–306. https://doi.org/10.62383/quwell.v2i2.2049